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Veljaca, Marija et al, The development of PL 14736 for treatment of inflammatory bowel disease, Advanced in GI pharmacology, 2002 O-32

Several studies have also highlighted a catalase deficiency (enzyme that neutralizes hydrogen peroxide) in the skin of vitiligo patients, which aggravates oxidative stress and cell death

The presence of primary cilia on islet cells is conserved across species (13) and has been shown to be critical for signaling of specific GPCRs to regulate islet insulin and glucagon secretion (14)

Funding and disclosures Both STEP UP trials were funded by Novo Nordisk A/S, the manufacturer of semaglutide